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A clinical trial to compare tiragolumab plus atezolizumab and chemotherapy with pembrolizumab and chemotherapy in people with untreated advanced non-small cell lung cancer
A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer
- Cancer
- Lung Cancer
- Non-Small Cell Lung Cancer (NSCLC)
Please note that the recruitment status of the trial at your site may differ from the overall study status because some study sites may recruit earlier than others.
Trial Status:
Active, not recruiting
This trial runs in
Cities
- A Coruña
- Aalst
- Aarau
- Adana
- Ankara
- Auckland
- Barcelona
- Barrie
- bei-jing-shi
- Berlin
- Bologna
- Bordeaux
- Brescia
- Bruxelles
- Busan
- c-r-o--ospedale
- Ceará
- Chang Wat Chiang Mai
- chang-sha-shi
- chang-zhou-shi
- Changhua County
- changwon-si
- Chattanooga
- Chemnitz
- Cheng Du Shi
- Chengde
- Chur
- Ciudad de México
- Cottingham
- Daegu
- Daejeon
- Diyarbakır
- Dongguan
- Edirne
- Edmonton
- Fairfax
- Firenze
- Fort Myers
- Fort Wayne
- Fukuoka
- Genova
- Hachioji
- Hamilton
- Hefei Shi
- Hirakata
- Hiroshima
- Hong Kong Island
- Ina
- İstanbul
- Ji Nan Shi
- jilin-city
- Karlsruhe
- Koto City
- Krung Thep Maha Nakhon
- Kurume
- Kyoto
- København
- L'Hospitalet de Llobregat
- Las Palmas de Gran Canaria
- Lexington
- linyi
- Lombardia
- London
- Los Angeles
- Lugo
- Madrid
- Mainz
- Marburg
- Marietta
- Marseille
- Montréal
- Nashville
- New Territories
- New York
- Nottingham
- Odense
- Orlando
- Osaka
- Osakasayama
- Oshawa
- Palma
- Palmerston North
- ping-xiang-shi
- Porto Alegre
- puc
- qing-dao-shi
- Rennes
- Rio Grande do Sul
- Roskilde
- Sakai
- San Luis Potosí
- Santiago de Querétaro
- Sault Ste. Marie
- Sendai
- Seoul
- Sevilla
- Sint-Niklaas
- St. Petersburg
- Strasbourg
- Suwon
- São Paulo
- Taichung City
- Taipei City
- takarazuka
- tambon-kho-hong
- Tauranga
- Torrance
- Toulouse
- Truro
- València
- Wakayama
- wei-fang-shi
- Whittier
- Wichita
- Wolverhampton
- wu-han-shi
- xi-an-shi
- xin-xiang-shi
- Yvoir
- zheng-zhou-shi
- Zürich
- Łódź
Trial Identifier:
NCT04619797 2022-502031-20-00 BO42592
Trial Summary
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin/cisplatin (Arm A) compared with placebo in combination with pembrolizumab plus pemetrexed and carboplatin/cisplatin (Arm B) in participants with previously untreated, locally advanced unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC). Eligible participants will be randomized in a 1:1 ratio to receive one of the following treatment regimens during the induction phase: * Arm A: Tiragolumab plus atezolizumab plus pemetrexed and carboplatin or cisplatin * Arm B: Placebo plus pembrolizumab plus pemetrexed and carboplatin or cisplatin Following the induction phase, participants will continue maintenance therapy with either tiragolumab in combination with atezolizumab and pemetrexed (Arm A) or placebo in combination with pembrolizumab and pemetrexed (Arm B).
Hoffmann-La Roche
Sponsor
Phase 2/Phase 3
Phase
NCT04619797, BO42592, 2022-502031-20-00
Trial Identifier
Tiragolumab, Atezolizumab, Pemetrexed, Carboplatin, Cisplatin, Tiragolumab Matching Placebo, Pembrolizumab
Treatments
Non-small Cell Lung Cancer (NSCLC)
Condition
Official Title
A Phase II/III, Randomized, Double-Blind, Placebo-Controlled Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Patients With Previously Untreated Advanced Non-Squamous Non-Small-Cell Lung Cancer
Eligibility Criteria
All
Gender
≥18 Years
Age
No
Healthy Volunteers
Inclusion Criteria
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
- Histologically or cytologically documented locally advanced unresectable or metastatic non-squamous NSCLC that is not eligible for curative surgery and/or definitive chemoradiotherapy
- No prior systemic treatment for metastatic non-squamous NSCLC
- Known tumor programmed death-ligand 1 (PD-L1) status
- Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST v1.1)
- Life expectancy >= 12 weeks
- Adequate hematologic and end-organ function
- Negative human immunodeficiency virus (HIV) test at screening
- Serology test negative for active hepatitis B virus or active hepatitis C virus at screening.
Exclusion Criteria
- Mutations in epidermal growth factor receptor (EGFR) gene or anaplastic lymphoma kinase (ALK) fusion oncogene
- Pulmonary lymphoepithelioma-like carcinoma subtype of NSCLC
- Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases
- Active or history of autoimmune disease or immune deficiency
- History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis
- History of malignancy other than NSCLC within 5 years prior to randomization, with the exception of malignancies with a negligible risk of metastasis or death
- Severe infection within 4 weeks prior to initiation of study treatment or any active infection that, in the opinion of the investigator, could impact patient safety
- Treatment with investigational therapy within 28 days prior to initiation of study treatment
- Prior treatment with CD137 agonists or immune checkpoint blockade therapies, including anti-cytotoxic T lymphocyte-associated protein 4, anti-TIGIT, anti-PD-1, and anti-PD-L1 therapeutic antibodies
- Treatment with systemic immunostimulatory agents within 4 weeks or 5 drug-elimination half-lives (whichever is longer) prior to initiation of study treatment
- Treatment with systemic immunosuppressive medication within 2 weeks prior to initiation of study treatment, or anticipation of need for systemic immunosuppressive medication during study treatment
- Known allergy or hypersensitivity or other contraindication to any component of the chemotherapy regimen the participant may receive during the study
- Women who are pregnant, or breastfeeding
- Known targetable c-ROS oncogene 1 (ROS1) or BRAFV600E genomic aberration.
For the latest version of this information please go to www.forpatients.roche.com